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Chicken Alfredo Lasagna

Chicken Alfredo Lasagna

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Indulge in the ultimate comfort food with this Chicken Alfredo Lasagna recipe, a heavenly blend of creamy Alfredo sauce, tender chicken, spinach, and layers of lasagna noodles, all smothered in melted mozzarella and Parmesan cheese. A perfect choice for those who adore rich and hearty meals!

Growing up in a family where the kitchen was the heart of our home, I was introduced to the art of fusion cooking early on. My grandmother, a traditional Italian cook, and my mother, an adventurous chef at heart, would often collaborate to create dishes that were both familiar and exciting. One such creation was Chicken Alfredo Lasagna, a dish that emerged on a rainy Sunday afternoon. As the rain pattered against the windows, we gathered in the kitchen, each bringing our favorite elements: my grandmother’s classic lasagna layers, my mother’s creamy Alfredo sauce, and my love for chicken and spinach. Together, we crafted a dish that was more than just food; it was a tapestry of our family’s culinary history, a delicious blend of tradition and innovation.

Why You’ll Love This Chicken Alfredo Lasagna

This Chicken Alfredo Lasagna isn’t just another recipe; it’s a culinary masterpiece that stands out in the world of comfort food. Its unique selling points include:

  • Fusion of Classics: Merging the beloved flavors of Fettuccine Alfredo with the structure of traditional lasagna creates a novel yet familiar taste sensation.
  • Rich and Creamy Sauce: The homemade Alfredo sauce, with its luxurious blend of heavy cream, Parmesan, and ricotta, elevates this dish to gourmet levels.
  • Nutrient-Rich Spinach: A twist of health in this indulgence, the addition of spinach adds a fresh, nutrient-packed dimension.
  • Customizable Protein: While chicken is the protein of choice here, this recipe welcomes variations, making it adaptable to different dietary preferences.
  • Perfect for Gatherings: Its sizable nature and universally loved flavors make it an ideal choice for family dinners or social gatherings.

Ingredients Notes

When embarking on the culinary journey of making Chicken Alfredo Lasagna, keep these ingredient notes in mind:

  • Lasagna Noodles: Opt for high-quality noodles for the best texture. Remember, they’ll be the foundation of your layers.
  • Fresh Ingredients: Use fresh baby spinach and garlic to ensure a burst of natural flavors.
  • Cheese Choices: Freshly grated Parmesan and mozzarella make a world of difference. The fresher, the better for that irresistible melt and flavor.
  • Chicken: Cooked and shredded chicken should be tender and well-seasoned. It’s the protein star of the dish!
  • Seasoning: Don’t skimp on the salt, pepper, and basil. They’re simple but essential for bringing out the rich flavors of the sauce and filling.

Step-by-Step Instructions

  1. Preparation: Start by preheating your oven and greasing your baking dish. This ensures a smooth release of the lasagna layers once cooked.
  2. Noodle Soaking: Soaking the noodles in hot water is crucial for a soft, easy-to-layer texture. This step cannot be skipped!
  3. Creating the Flavor Base: Cooking the onion and garlic in butter forms the aromatic backbone of the dish. This step infuses the sauce with depth and warmth.
  4. Incorporating Greens: Adding spinach not only introduces a health element but also adds a subtle, earthy flavor that balances the richness of the cheeses.
  5. Sauce Preparation: The heart of the dish, where heavy cream, cheeses, and seasonings are combined. Achieving the right consistency here is key for layering.
  6. Assembly: Layering starts with sauce, then noodles, more sauce, and cheese. The order is crucial for a cohesive structure and even distribution of flavors.
  7. Baking to Perfection: Covered baking followed by a brief broil ensures a perfectly cooked interior and a beautifully browned top.
  8. Resting and Serving: Allowing the lasagna to rest ensures it sets properly and makes for easier serving. This step requires patience but is worth it for the perfect slice.

Storage Options

Once you’ve enjoyed your Chicken Alfredo Lasagna, storage is simple yet crucial for maintaining its quality. The lasagna can be stored in the refrigerator for up to 5 days. Make sure to cover it tightly with plastic wrap or aluminum foil. For longer storage, this lasagna freezes beautifully. Simply cut it into individual portions, wrap each piece well, and freeze. To reheat, thaw overnight in the refrigerator and bake in the oven until heated through.

Variations and Substitutions

  • Gluten-Free Noodles: Substitute regular lasagna noodles with gluten-free ones for those with dietary restrictions.
  • Vegetarian Version: Skip the chicken and double up on the spinach, or add other vegetables like mushrooms or zucchini.
  • Different Cheeses: Feel adventurous? Try incorporating Gouda or Fontina for a twist in flavor.
  • Protein Variations: Not a chicken fan? Use ground beef, turkey, or even shrimp for a different protein punch.
  • Spice It Up: Add red pepper flakes to the Alfredo sauce for those who enjoy a bit of heat in their meals.

Chicken Alfredo Lasagna

Indulge in the ultimate comfort food with this Chicken Alfredo Lasagna recipe, a heavenly blend of creamy Alfredo sauce, tender chicken, spinach, and layers of lasagna noodles, all smothered in melted mozzarella and Parmesan cheese. A perfect choice for those who adore rich and hearty meals!
3.30 from 55 votes
Print Pin Rate
Course: Main Course
Cuisine: Italian
Prep Time: 20 minutes
Cook Time: 45 minutes
Total Time: 1 hour 5 minutes
Servings: 12


  • Lasagna Noodles: 12-15 pieces
  • Unsalted Butter: 2 tablespoons
  • Garlic Minced: 4 cloves
  • Onion Finely Chopped: 1 small
  • Fresh Baby Spinach: 10 oz
  • Heavy Cream: 4 cups
  • Parmesan Cheese Freshly Grated: 1 1/2 cups
  • Ricotta Cheese: 15 oz
  • Dried Basil: 1 teaspoon
  • Cooked and Shredded Chicken: 3 cups
  • Mozzarella Cheese Grated: 4 cups
  • Kosher Salt and Freshly Ground Black Pepper: To taste
  • Fresh Parsley Minced (Optional): For serving


  • Begin by preheating the oven to 350°F (175°C). Concurrently, grease a 9×13-inch baking dish using butter or nonstick spray. Set this aside for subsequent use.
  • Arrange the lasagna noodles in a separate 9×13-inch pan or a comparable long and shallow dish. Submerge the noodles completely by pouring hot water over them. Let them soak for a minimum of 30 minutes, periodically agitating them with your hands to prevent sticking.
  • Utilize a large skillet and heat it over medium-high heat. Commence by adding butter, followed by the chopped onion. Cook the onion until it reaches a translucent state, approximately 10 minutes. Subsequently, incorporate the minced garlic and continue cooking for an additional 2 minutes.
  • Introduce the fresh baby spinach into the skillet. Cook briefly, just until the spinach wilts.
  • Add the heavy cream to the skillet, along with dried basil, and a generous quantity of salt and pepper. Bring the mixture to a simmer. Following this, stir in the Parmesan and ricotta cheeses until they are thoroughly melted. Finally, integrate the shredded chicken into the mixture and remove the skillet from heat. If the mixture appears overly liquid, it may be simmered for a few more minutes to achieve the desired thickness.
  • Spread a spoonful of the Alfredo sauce mixture evenly across the bottom of the prepared baking dish. Over this sauce layer, arrange a layer of the pre-soaked noodles.
  • On top of the first noodle layer, apply approximately one-third of the Alfredo sauce mixture. Follow this with a layer of one-third of the grated mozzarella cheese. Continue this layering process until all ingredients are utilized, ensuring that mozzarella cheese forms the final top layer.
  • Cover the baking dish with foil and bake in the preheated oven for 45 minutes. For a browned cheese topping, optionally uncover the dish and broil for 2-3 minutes.
  • After baking, allow the lasagna to rest for 10 minutes before serving. This resting period is essential for the lasagna to set properly. Optionally, garnish with minced fresh parsley. Serve and enjoy.
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